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alleles are enriched in mutation-intolerant genes and in regions
under strong background selection" (2018)
of schizophrenia GWAS data from samples of European ancestry
(N=105,318; 40,675 cases and 64,643 controls)
Freq.A1: Frequency of effect allele in 1000
CHR: Chromosome code.
BP: Base-pair position.
A1: Effect allele.
A2: Non-effect allele.
OR: Odds ratio.
SE: Standard error of the regression beta
file supplies SNP names of high-quality imputed (INFO > 0.9)
markers, in LD-Score --merge-alleles
Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S,
Carrera N, et al. Common schizophrenia alleles are enriched in
mutation-intolerant genes and in regions under strong background
selection. Nat Genet. 2018. doi: 10.1038/s41588-018-0059-2.
31/05/2018: Corrected OR of X-chromosome SNP rs5937157, which was
shown as a regression beta. Thanks to Lucy Riglin for
reporting this error.
"A genome-wide association
study in individuals of African ancestry reveals the importance of
the Duffy-null genotype in the assessment of clozapine-related
of lowest absolute neutrophil count during clozapine treatment in
individuals of African ancestry (N=552)
SNP name in HRC
A2: Non-effect allele.
Freq: Frequency of effect allele.
Linear mixed model regression statistic.
se: Standard error of the regression beta.
Legge SE, Pardiñas
AF, Helthuis M, Jansen JA, Jollie K, Knapper S, et al. A
genome-wide association study in individuals of African ancestry
reveals the importance of the Duffy-null genotype in the assessment of
clozapine-related neutropenia. Mol Psych. 2019. doi: